I do not build my bows symetrical. For me, the most crucial factors are:
1) If there are potentially weak/problematic spots I try to put these in the upper limp. The lower limp has to bend more, weak spots are more stressed (if you let them bend)
2) If there is a reflex, I try to to put it in the lower limp, so it becomes faster. I put a deflex in the upper limp.
3) I ask myself which choice of limps favors the string (as MWirwicki said, less Archers Paradox)
4) aesthetics