Has any of the computer design guys approached the tiller in such a manner with success?
I haven't. I trusted the design completely and just made the bow(s) to final dimensions as closely as I could, then put them on the tree and worked them out to full draw. IIRC, the maple bow I did this way I did actually do a bit of fine tuning on the tiller in the end, but very little. The red oak lam bow I just exercised out to full draw with no touch ups at all.
The big questions (for me, maybe not you and Alan) are how consistent the wood is in matching the bend test samples over the full length of the bow and how accurately the bow is made to the design dimensions. If these two things are good then you won't need more tillering than very small fine tuning adjustments, if anything at all.
Using laminations helps with the consistency of the material properties, but I don't think you are allowed to do that for your flight bow.
Mark