Yes it will change drastically. As you deflex, you decrease your leverage at the tips, reducing strain in the outer limbs, forcing the inner limbs to take more strain than the outer. Deflex limbs require thicker limbs to counter this. Actually, ANY and ALL deflexed portions of a limb will REQUIRE the deflex to be thicker or it will hinge due to increase leverage over that area. This is why deflex bows, in my experience, are more efficient than reflexed bows, even if slower. They store less energy due to lower string tension, but that energy is more efficiently used because the thicker inner limbs are less likely to take set, combined with the reduced radius they bend to store a set amount of energy.