I got the impression that I should be trying for the least number of nodes in the working limb.
This is my mindset. If you know your tips will be stiff you can discount that area too and let the nodes fall where they fall there. Then equal distance for one node in the working limb.
You will normally have one more (in the working section) to deal with on one side. I rather that one be closer to the inners just so that you can adjust tiller if you need too. Nodes close to where the tips transition from working to non working scare me. I try and avoid nodes there as I've had a bow break right after the node near the tips.
I don't care about nodes near the handle. The more there the better IMO.
Each boo piece is different though.
In your pic, I would make that mid limb node equal distance from the tips on both sides. The handle area node should be non working and try and keep that tip node in a non working part of the tips.
I'm not saying this is the only way. This is just my my thought process. I know some don't pay much attention to node spacing and their bows turn out fine.