My neighbour was a bee keeper and he kept a small hive with a glass front on his mantle. It had a wire mesh tunnel leading outside. Very cool to watch. Anyway if his arthritis was acting up he would just grab a few bees out of the hive and get them to sting his knuckles. He claimed it worked.
The worst, meanest thing I've heard of is going out at night with a garbage can and knocking the nest into the can. Slam the lid and put the garbage out.