Brad, very good inquisitive question. But no. If, for instance, the bottom limb has 3" of reflex and the top is even with the handle, when dynamic balance is achieved at full draw, the top limb will likely be drawn farther behind the handle than the bottom, but the arrow will come straight back relative to the shelf/handle, without causing the bow to tip in the hand.
Folks often ask... "One tip is ahead of the other... should I level the tips or the handle in the tree?" Definitely level the handle. That's how you intend to hold it, right?