When you look at Gordon's bow you may get the impression that the drawn tiller does look goofy. But the real goofy part would have been if he had tried to make it look symmetrical. In other words, Gordon nailed that tiller perfectly.
Understand that that reflexed area on the lower limb was going to stress the inner limb/near handle and that he needed to apply the correct limb design to the upper limb to compensate. A good lessen in proper tillering there folks.
So to answer you question, no, there wouldn't be any performance loss if you design/execute tiller each limb appropriately. ........Art