Making a quad lam would be no harder than a tri lam. Just slightly more labour intensive. You'd have to make sure your lams weren't too thick, especially the core lams. I often make tri lams, because I can make more bows with less wood. I need less precious belly wood to make a bow. They also look very nice with contrasting woods.
Proper glue lines are not weak. If done correctly, they're stronger than the surrounding wood. I've never had a glue line failure on any bow, including heavy warbows. The wood itself always fails first. You'd also have to watch that your limb's physical weight didn't get too high using dense core layers. I don't believe there is any advantage to making a quad lam over a tri lam.