Basically, the stress put on an all wood bow (even with sinew) causes the wood to take on set. Because the wood always gives in a bit, starting out with reflex helps in ending up with a straight standing bow.
How much set depends can depend on a few factors. Moisture content is one of them. If your bow wood is high in moisture, or hasn't been seasoned enough it will likely take on considerably more set than if adequately dry.
Also, minimizing the stress during the build process helps. Never exceed your intended draw weight while tillering. While on the bow scale during the tillering process, if you're bow reads your intended weight at 18" of draw stop there, identify any stiff spots, remove wood there. If it's bending in a nice arc, remove wood evenly on the limbs then put back on the wall (scale). Keep strategically removing wood on the belly until you are able to pull the bow to your draw length at the intended draw weight.