When making the front profile of your bow, decide how wide your limbs will be. Then mark from the ouside of that knot half the width of the limb on both sides. Follow the grain around the knot then tiller the bow as if that knot wasnt there. I dont believe it will cause too much trouble though because it is near the stiff non working handle and this knot may cause you no trouble at all.
EDIT: After looking again at your stave, I bet if you moved your bow far enough to the other side away from the knots, you could lay out your bow and avoid the knots all togeather, with only showing a bit of curve in the profile where the knots were. Just follow the grain around them. How wide is the stave at the knots???