Most of the bows I've made have been wrong-handed for me, since I'm a lefty. I've always done similar to George, or sometimes I'll just put some painters tape on the other side to avoid scratching the finish and then shoot off my fist. I didn't realize the bow itself would have to "learn" anything different between being shot left or right handed?? It would seem to me that the string is still being pulled back on the same plane either way. The only thing different I can see is that on one side it might be closer to center-shot than the other (if you cut a shelf into your bows), but you can just adjust your aim accordingly when shooting it in.
These are just my thoughts, I'd be happy to hear any opinions to the contrary.