There have been numerous groups across the world (Africa, Asia and South America) that used it on darts and/or arrows so I don't think it ruins the meat. If the meat was poison, the people would have died and the info wouldn't have been passed down. It could be mixed with wolfsbane, opium or many other ingredients. Don't be fooled though, it is deadly by itself. People have used tobacco poultice over the years also. But when the juice containing high grade nicotine and saliva was scraped from pipes and used, many people were poisoned.
They also sprinkled tobacco into water to numb the fish.
If that isn't enough info, read "African ethnobotany: poisons and drugs : chemistry, pharmacology, toxicology " By Hans Dieter Neuwinger