Jesse,
I use 16 strands for the main string and 18 for the loops - so they are padded a little. If you are going to use self-nocks with FF strings you need to make sure you nicely round down and smooth the 'shoulders' of your nocks. The shoulder is that point where the grove intersects the face of the bow nearest the handle. If there are any sharp points there, FF will catch on them and potentially slice right right down the nock's edge. I also burnish the groves and shoulders with a steel rod for extra protection.
For softer woods like yew, juniper, cascarra and hazelnut, you're better off using overlays. But for harder woods like osage, hickory, ipe, and maple you really don't need them if you do what I described above.